1、主持国家自然科学基金(Hedgehog/Gli1信号通路调控EMX2表达在肺鳞癌EMT转化和侵袭转移过程中的作用及机制研究编号81501983)。
2、作为项目子课题骨干参与2016年国家精准医学研究重点专项(肺癌诊疗规范及应用方案的精准化研究)。
3、第二负责人完成天津市科委面上项目(含有肺泡癌成分的腺癌和单纯性腺癌的基因组比较分析编号12JCYBJC17800)。
4、第三负责人完成国家自然科学基金(单纯性细支气管肺泡癌进展为混合性细支气管肺泡癌的信号通路研究)。
5、第五负责人完成国家自然科学基金(非小细胞肺癌OPN对TAM的功能调控研究)。
发表学术论文10余篇,其中sci收录第一作者文章4篇,累计影响因子超过15分。
部分文章如下:
1)Yue D, Li H, Che J, Zhang Y, Tseng HH, Jin JQ, Luh M, Giroux-Leprieur E, Mo M, Zheng Q, Shi H, Zhang H, Hao X1, Wang C, Jablons DM, He B. Hedgehog/Gli promotes epithelial- mesenchymal transition in lung squamous cell carcinomas. J Exp Clin Cancer Res, 2014, 33:34.
2)Yue D, Gong L, You J, Su Y, Zhang Z, Zhang Z, Gu F, Wang M, Wang C. Survival analysis of patients with non-small cell lung cancer who underwent surgical resection following 4 lung cancer resection guidelines. BMC Cancer, 2014, 14:422.
3) Yue D, Li H, Che J, Zhang Y, Tolani B, Mo M, Zhang H, Zheng Q, Yang Y, Cheng R, Jin JQ, Luh TW, Yang C, Tseng HH, Giroux-Leprieur E, Woodard GA, Hao X, Wang C, Jablons DM, He B*.EMX2 Is a Predictive Marker for Adjuvant Chemotherapy in Lung Squamous Cell Carcinomas.PLoS One. 2015,10(7):e0132134.
4)Li H, Yue D, Jin JQ, Woodard GA, Tolani B, Luh TM, Giroux-Leprieur E, Mo M, Chen Z, Che J, Zhang Z, Zhou Y, Wang L, Hao X, Jablons D, Wang C, He B.Gli promotes epithelial-mesenchymal transition in human lung adenocarcinomas.Oncotarget. 2016, 7(49):80415-80425.
5)岳东升,王长利。非小细胞肺癌的手术标准及预后分析。中华肿瘤杂志,2014,36(7): 532-535。
6)岳东升,车娟娟,李跃,张华,王长利。肺鳞状细胞癌450例预后分析。中华外科杂志,2013, 51(2):161-165。
7) G Bosco-Clément, F Zhang, Z Chen, H-M Zhou, H Li, I Mikami, T Hirata,AYagui-Beltran, N Lui, H T Do, T Cheng, H-H Tseng, H Choi, L-T Fang,I-J Kim, D Yue, C Wang, Q Zheng, N Fujii, M Mann, D M Jablons and B He. Targeting Gli transcription activation by small molecule suppresses tumor growth. Oncogene, 2014, 33(16): 2087-2097.
8) Li H, Lui N, Cheng T, Tseng HH, Yue D, Giroux-Leprieur E, Do HT, Sheng Q, Jin JQ, Luh TW, Jablons DM, He B. Gli as a novel therapeutic target in malignant pleural mesothelioma.PLoS One, 2013, 8(3):e57346.
9) Zhang Y, He J, Zhang F, Li H, Yue D, Wang C, Jablons DM, He B, Lui N. SMO expression level correlates with overall survival in patients with malignant pleural mesothelioma. J ExpClin Cancer Res, 2013, 32:7.
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