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应国光，博士，教授，PI，博士生导师。天津市肿瘤研究所副所长，肿瘤细胞生物学实验室主任。天津市肿瘤防治重点实验室主任，天津市医学健康领域重点实验室创新战略联盟理事长。毕业于清华大学化学系、都灵大学医学院和米兰Mario Negri药理研究所。1986-1992年上海生物制品研究所国家科委基因工程中心助研。2007年任职于天津医科大学附属肿瘤医院。历年主要学术贡献包括：参与完成国家863计划人基因工程产品的中试研究及产业化开发，获国家科技进步一、二等奖。克隆鉴定T160/SSRP1与cross-form DNA的相互作用，提出结构识别为特征的基因扩增及转录调控假说。发现Nucleolin为Myb原癌基因转录协同子以及不同Myb分子的组织特异转录活性机制。发现FPRL1/FPR2为神经细胞保护因子Humanin的天然受体，阐明Humanin抗Aβ的神经保护机制。最先展开具有特异膜调控潜能的EHD新基因家族的系统比较与功能研究，并围绕膜转运机制对关键受体胞内转运与细胞信号传导、其异变在肿瘤中的生物学作用及其临床转化应用前景、路线和策略等方面进行探索。学术论文四十余篇发表于The Journal of Biological Chemistry、the Journal of Immunology等国际专业期刊。
主要奖励
1992欧共体玛丽亚·居里奖学金
1993中国国家科技进步一等奖，人基因工程a1干扰素的研制，主要研制者之一
1994意大利肿瘤合作协会奖学金
1995中国国家科技进步二等奖，人基因工程γ干扰素的研制、中试生产及临床应用，主要研制者之一
1995卫生部科技进步一等奖，基因工程γ干扰素的研制、中试生产及临床应用，主要研制者之一
研究基金
2008.1-2010.12 EHD蛋白对ErbB受体的转运调控机制研究,国家自然科学基金，主持项目。
2009.10-2012.9非激素依赖性前列腺癌的蛋白组学和分子靶向研究,天津市科委CMM-天津合作基金，合作项目。
2010.1-2014.8 iCSCs侵袭和转移相关预警分子筛查及意义研究(肿瘤干细胞在恶性肿瘤发生发展中的作用及机理研究)，国家973计划项目子课题，合作项目。
2011.1-2013.12膜转运调节蛋白EHD的核功能及其影响乳腺病变的机制研究，国家自然科学基金,主持项目。
2012.1-2014.12天津滨海新区联合攻关合作项目。
特约审评
2001- The Journal of Biological Chemistry; International Journal of Pharmacology; International Journal of Radiation, Oncology and BioPhysics
学术兼职
2009-中华医学会医学细胞生物学分会委员
2011-中国抗癌协会肿瘤病因学分会委员
2011-中国抗癌协会肿瘤转移分会委员
2011- 《中国肿瘤临床》副主编
2011- 《Clinical Oncology and Cancer Research》编委
近三年主要论文
1. Chen,Y.Z., Chen,Z., Gong,Y.A., and Ying,G. 2012. SUMOhydro: A Novel Method for the Prediction of Sumoylation Sites Based on Hydrophobic Properties. PLoS One 7:e39195.
2. Duo,J., Ying,G.G., Wang,G.W., and Zhang,L. 2012. Quercetin inhibits human breast cancer cell proliferation and induces apoptosis via Bcl-2 and Bax regulation. Mol Med Report. 5:1453-1456.
3. Li,H., Wu,J., Ying,G., Chen,L., Lai,L., Liu,Z., Zhang,N., and Guo,H. 2012. J-4: a novel and typical preclinical anticancer drug targeting protein kinase C zeta. Anticancer Drugs 23:691-697.
4. Ding,T., Ma,Y., Li,W., Liu,X., Ying,G., Fu,L., and Gu,F. 2011. Role of aquaporin-4 in the regulation of migration and invasion of human glioma cells. Int J Oncol 38:1521-1531.
5. Duan,L., Raja,S.M., Chen,G., Virmani,S., Williams,S.H., Clubb,R.J., Mukhopadhyay,C., Rainey,M.A., Ying,G., Dimri,M. et al 2011. Negative regulation of EGFR-Vav2 signaling axis by Cbl ubiquitin ligase controls EGF receptor-mediated epithelial cell adherens junction dynamics and cell migration. J Biol Chem 286:620-633.
6. George,M., Rainey,M.A., Naramura,M., Foster,K.W., Holzapfel,M.S., Willoughby,L.L., Ying,G., Goswami,R.M., Gurumurthy,C.B., Band,V. et al 2011. Renal Thrombotic Microangiopathy in Mice with Combined Deletion of Endocytic Recycling Regulators EHD3 and EHD4. PLoS One 6:e17838.
7. Ma,Y., Wang,B., Li,W., Liu,X., Wang,J., Ding,T., Zhang,J., Ying,G., Fu,L., and Gu,F. 2011. Intersectin1-s is involved in migration and invasion of human glioma cells. J Neurosci. Res 89:1079-1090.
8. Wang,B., Yang,D., Sun,B., Wei,X., Guo,H., Liu,X., Ying,G., Niu,R., Zhang,N., and Ma,Y. 2011. An anti-tumor nanoparticle, [Gd@C82(OH)22]n, induces macrophage activation. J Nanosci Nanotechnol 11:2321-2329.
9. Chen,K., Le,Y., Liu,Y., Gong,W., Ying,G., Huang,J., Yoshimura,T., Tessarollo,L., and Wang,J.M. 2010. A critical role for the g protein-coupled receptor mFPR2 in airway inflammation and immune responses. J Immunol 184:3331-3335.
10. Duan,L., Chen,G., Virmani,S., Ying,G., Raja,S.M., Chung,B.M., Rainey,M.A., Dimri,M., Ortega-Cava,C.F., Zhao,X. et al 2010. Distinct roles for Rho versus Rac/Cdc42 GTPases downstream of Vav2 in regulating mammary epithelial acinar architecture. J Biol Chem 285:1555-1568.
11. George,M., Rainey,M.A., Naramura,M., Ying,G., Harms,D.W., Vitaterna,M.H., Doglio,L., Crawford,S.E., Hess,R.A., Band,V. et al 2010. Ehd4 is required to attain normal prepubertal testis size but dispensable for fertility in male mice. Genesis 48:328-342.
12. Ma,Y., Wang,B., Li,W., Ying,G., Fu,L., Niu,R., and Gu,F. 2010. Reduction of intersectin1-s induced apoptosis of human glioblastoma cells. Brain Res 1351:222-228.
13. Rainey,M.A., George,M., Ying,G., Akakura,R., Burgess,D.J., Siefker,E., Bargar,T., Doglio,L., Crawford,S.E., Todd,G.L. et al 2010. The endocytic recycling regulator EHD1 is essential for spermatogenesis and male fertility in mice. BMC Dev Biol 10:37.
14. Wu,J., Zhang,B., Wu,M., Li,H., Niu,R., Ying,G., and Zhang,N. 2010. Screening of a PKC zeta-specific kinase inhibitor PKCzI257.3 which inhibits EGF-induced breast cancer cell chemotaxis. Invest New Drugs 28:268-275.
15. Guo,H., Ma,Y., Zhang,B., Sun,B., Niu,R., Ying,G., and Zhang,N. 2009. Pivotal Advance: PKCzeta is required for migration of macrophages. J Leukoc Biol 85:911-918.
16. Liu,Y., Wang,J., Wu,M., Wan,W., Sun,R., Yang,D., Sun,X., Ma,D., Ying,G., and Zhang,N. 2009. Down-regulation of 3-phosphoinositide-dependent protein kinase-1 levels inhibits migration and experimental metastasis of human breast cancer cells. Mol Cancer Res 7:944-954.
17. Zhang,B., Ma,Y., Guo,H., Sun,B., Niu,R., Ying,G., and Zhang,N. 2009. Akt2 is required for macrophage chemotaxis. Eur J Immunol 39:894-901.
18. Zhang,F., Zhang,L., Zhang,B., Wei,X., Yang,Y., Qi,R.Z., Ying,G., Zhang,N., and Niu,R. 2009. Anxa2 plays a critical role in enhanced invasiveness of the multidrug resistant human breast cancer cells. J Proteome Res 8:5041-5047.
（肿瘤细胞生物学实验室）
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